I use trillian for AIM and Yahoo, but I think I only have 5 or 6 people on my AIM list (1 on Yahoo), of which I speak to 2 people regularly, the rest I just use it as a backup for MSN. Do like the fact that you can set away messages using Trillian!
MSN I use with their own client (instead of putting it through trillian), simply because it means I can use my webcam, personalised emotes, and all the other funky features.
Skype is always the best for microphone using though!


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